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Le NMN peut améliorer la dérégulation métabolique du NAD+ après une infection au covid-19

Le NMN peut améliorer la dérégulation métabolique du NAD+ après une infection au covid-19

Aug 18, 2022

Le 29 avril 2022, la recherche préclinique de l'Académie chinoise des sciences, de l'Université de Pékin et de l'Université Tsinghua a montré que la supplémentation en NMN peut sauver le métabolisme du NAD + , la réponse immunitaire et la dérégulation de l'expression génique liée à la mort cellulaire causée par une nouvelle infection à coronavirus, inhiber la mort cellulaire chez la souris, et améliorer de manière significative la pneumonie causée par une infection virale. Les résultats de la recherche ont été inclus dans la revue faisant autorité "Cell Discovery".



In this study, the researchers found that Covid-19 infection caused genetic dysregulation in mice, and that these dysregulations were associated with NAD+ metabolism, immune response and cell death, which are very similar to the symptoms of Covid-19 patients. With NMNd treatment, the researchers found that, first, the pneumonia phenotype, including excessive inflammatory cell infiltration, hemolysis, and embolism in the lungs infected with COVID-19, was significantly improved. Second, supplementation with NAD+ and NMN significantly inhibited cell death. Even more strikingly, NMN supplementation averted death in 30% of aged mice infected with a lethal dose of Covid-19. Finally, mechanistically, the researchers found that supplementation with NAD+ or NMN could partially rescue the gene expression and metabolic disturbances caused by Covid-19 infection, thereby saving the lives of mice.

The results of this study support a new crown treatment experiment targeting the NAD+ pathway. The NAD+ precursor represented by NMN has become one of the bright spots. Structurally, NMN is the closest to NAD+ and can be converted to NAD+ in just one step. NMN-related industries, as intermediates for new crown treatment drugs, have a huge market and may attract new opportunities.


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